ORTHO ANISIDINE
o-Anisidine
CAS: 90-04-0
Molecular Formula: C7H9NO
ORTHO ANISIDINE - Names and Identifiers
ORTHO ANISIDINE - Physico-chemical Properties
| Molecular Formula | C7H9NO |
| Molar Mass | 123.15 |
| Density | 1.092g/mLat 25°C(lit.) |
| Melting Point | 3-6°C(lit.) |
| Boling Point | 225°C(lit.) |
| Flash Point | 210°F |
| Water Solubility | 13 g/L (20 ºC) |
| Solubility | 14g/l |
| Vapor Presure | <0.1 at 25 °C (NIOSH, 1994) |
| Appearance | Powder/Solid |
| Color | Off-white |
| Exposure Limit | Potential occupational carcinogen. NIOSH REL: TWA 0.5 mg/m3, IDLH 50mg/m3; OSHA PEL: TWA 0.5 mg/m3; ACGIH TLV: TWA 0.1 ppm (adopted). |
| Merck | 14,667 |
| BRN | 386210 |
| pKa | 4.52(at 25℃) |
| PH | 7.3 (1g/l, H2O, 20℃) |
| Storage Condition | Refrigerator |
| Stability | Stable. Incompatible with strong oxidizing agents, acid anhydrides, chloroformates, acids, some plastics, rubber. Air sensitive. |
| Sensitive | Light Sensitive |
| Refractive Index | n20/D 1.574(lit.) |
| Physical and Chemical Properties | Character light red or light yellow oily liquid, exposed to the air to become light brown. melting point 6.2 ℃ boiling point 224 ℃ relative density 1.0923 refractive index 1.5730 soluble in dilute inorganic acid, ethanol and ether, slightly soluble in water. |
| Use | For dyes, fragrances and pharmaceutical intermediates |
ORTHO ANISIDINE - Risk and Safety
| Risk Codes | R45 - May cause cancer R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R68 - Possible risk of irreversible effects |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2431 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | BZ5410000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 29222200 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | Acute oral LD50 for rats 2,000 mg/kg, wild birds 422 mg/kg, mice 1,400 mg/kg, rabbits 870 mg/kg (quoted, RTECS, 1985). |
ORTHO ANISIDINE - Upstream Downstream Industry
| Raw Materials | 1-Chloro-2-nitrobenzene Methyl alcohol Sodium hydroxide |
| Downstream Products | Guaiacol |
ORTHO ANISIDINE - Nature
Open Data Verified Data
light red or light yellow oily liquid that turns light brown when exposed to air. The relative density was 1. 0923. Boiling point 224 °c. Melting point 6.2 °c. Refractive index 1. 5730, flammable. Can be volatilized with steam. Soluble in dilute inorganic acid, ethanol and ether, water-soluble.
Last Update：2025-06-10 22:55:16
ORTHO ANISIDINE - Preparation Method
Open Data Verified Data
O-nitrochlorobenzene is used as a raw material to carry out methoxylation reaction with methanol and sodium hydroxide to generate O-nitroanisole, which is then reduced with sodium sulfide. The reaction product is separated and the residue is removed by distillation under reduced pressure to obtain the finished product O-aminoanisole.
Last Update：2022-01-01 10:51:53
ORTHO ANISIDINE - Application
Open Data Verified Data
can be used for the preparation of azo dyes, ice dyes and chromophenol AS-OL and other dyes as well as guaiacol, anliping medicine. Vanillin can also be prepared.
Last Update：2025-08-19 16:24:40
ORTHO ANISIDINE - Safety
Open Data Verified Data
- This product is highly toxic. Irritation of the skin and mucous membranes, causing allergies. The maximum allowable concentration in air is 0.5 mg/m3. Its toxicity and protection methods see aniline and p-aminophenyl ether.
- packaged in iron drum, 200kg per barrel. Store in a dry, ventilated place, avoid sun, moisture, heat. It shall be stored and transported according to the regulations on flammable and toxic dangerous goods.
Last Update：2025-06-10 22:55:16
ORTHO ANISIDINE - Reference Information
| Henry's Law Constant | 1.25 at 25 °C (approximate - calculated from water solubility and vapor pressure) |
| (IARC) carcinogen classification | 2A (Vol. Sup 7, 73, 127) |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | O-methoxyaniline as a dye intermediate for the dye industry: used as a corrosion inhibitor for steel preservation; Used as an antioxidant for some resins; in some European countries, it is used in the manufacture of medicinal products and chemical textiles. |
| exposure route | workers engaged in the production of azo dyes may be poisoned by exposure to this substance; it was also found to contain O-methoxyaniline in cigarette smoke, so smoking may lead to poisoning; O-methoxyaniline was found in the emissions of chemical plants and petroleum refineries. |
| Use | used as dye, perfume and pharmaceutical intermediates can be used in the preparation of azo dyes, ice dye and phenol AS-OL and other dyes and guaiacol, Anli equal medicine. Vanillin can also be prepared. as an intermediate of medicine and dye, it is also used in the preparation of vanillin in the food industry as a complexing indicator for the determination of Mercury, an intermediate of azo dye and a bactericide, a dye, perfume and pharmaceutical intermediates microcrystallite analysis to examine cyanide. Mercury is titrated with a complexing indicator. Organic Synthesis. |
| production method | It is obtained by reduction of O-nitroanisole, which can be obtained by O-nitrochlorophenoxy [91-23-6], the reducing agent may be sodium sulfide or iron powder. In addition, O-methoxyaniline can also be prepared from O-nitrophenol by methylation and reduction. Raw material consumption quota: O-nitrochlorobenzene 1301kg/t, methanol (98%)395kg/t, sodium sulfide (60%)1128kg/t, caustic soda (96%)457kg/t. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 2000 mg/kg; Oral-mouse LD50: 1400 mg/kg |
| flammability hazard characteristics | open flame flammable; Toxic aniline gas emitted by heat |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| fire extinguishing agent | water, carbon dioxide, sand, dry powder |
| Occupational Standard | TWA 0.5 mg/m3; Tel 1.5 mg/m3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
| immediate life-threatening and health concentration | 50 mg/m3 |
Last Update：2024-04-09 15:16:53
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Raw Materials for ORTHO ANISIDINE
Downstream Products for ORTHO ANISIDINE